AB0292 A CROSS-SECTIONAL STUDY OF THE CENTRAL SENSITIVITY SYNDROME USING THE CENTRAL SENSITIZATION INVENTORY IN PATIENTS WITH RHEUMATOID ARTHRITIS

Background Despite having low levels of inflammation, 47.3% patients with rheumatoid arthritis (RA) continued to report moderate-to-high pain and fatigue [1], indicating that chronic can interfere disease activity assessment. And have linked central sensitization syndromes (CSSs) [2]. The inventory (CSI) is a valid reliable tool for detecting CSS, its severity, associated [3]. However, there been few reports CSS in RA being analysed CSI. Objectives This study aims conduct cross-sectional analysis using the CSI investigate relationship activity. Methods We performed retrospective, on 269 consecutive (70 males 196 females; mean ± SD = 69.9 12.2 years, range: 27–92 years; SD, duration: 12.9 10.4 0–55 DAS28CRP: 1.89 0.78; 0.99–4.88). Patients were evaluated by CSI; clinical laboratory examinations all same day. SJC, TJC, CRP, ESR, PtVAS, VAS, DAS28CRP, DAS28ESR, HAQ-DI, CDAI compared “CSS group (CSI ≧ 40)” “non-CSS < [4]. Furthermore, between each parameter was also investigated. Results had 18.4 14.6. ≥ 40 found 9.6% (26 patients). number PtGA, CDAI, HAQ-DI significantly higher group” than (Table 1). PtGA (r 0.352, p 0.001), VAS 0.369, 0.253, 0.477, 0.001) significant correlations Table 1. Compared non-CSS group(n=26) Mean±SD, % (n=243) value Disease duration (years) 15.4±11.3 12.6±10.3 0.202 Steinbrocker stage 1 2/3 4(%) 26.9/73.1 45.9/54.1 0.064 Tender joint count (0-28) 0.7±0.9 0.4±0.9 0.054 Swollen 0.2±0.5 0.4±1.0 0.389 CRP (mg/dl) 0.38±0.67 0.47±1.02 0.874 ESR (mm) 15.4±16.9 18.0±18.3 0.636 (VAS/100mm) 37.3±24.2 20.2±23.7 <0.001* DAS28CRP 2.14±0.80 1.85±0.77 0.068 5.23±28.4 3.46±3.82 <0.01* Pain VAS/100mm 42.1±28.4 19.4±23.2 1.41±0.97 0.40±0.64 *significant Conclusion In patients, not inflammation (CRP or ESR) but related subjective assessment (PtGA VAS), functional impairment, (CDAI). may influence assessment, treatment improve impairment. References [1] Lee YC, et al. Subgrouping based pain, fatigue, psychosocial factors. Arthritis Rheumatol. 2014; 66(8): 2006–2014. [2] Tanaka K, Validation Japanese version Central Sensitization Inventory musculoskeletal disorders. PLoS One. 2017; 12(12):e0188719. [3] Mayer TG, development psychometric, validation inventory. Pract. 2012; 12(4):276–285 [4] Neblett R, (CSI): establishing clinically values identifying sensitivity an outpatient sample. J Pain. 2013; 14(5):438-45. Acknowledgements: NIL. Disclosure Interests None Declared.